Abstract
Periodic Acceleration (pGz) is a novel method of cardiopulmonary support. It is performed by a motion platform which moves the supine body head-ward to foot ward, and back. The forces imparted by this movement are quantitated along the spinal axis (z-plane) in a subject. These acceleration-deceleration forces generate changes in intrathoracic pressure and mechanical motion of the diaphragm producing a net forward movement of blood flow. Additionally, ventilation with low tidal volumes is also produced when pGz is applied. Furthermore, the imparted Gz forces also impose pulsatile shear stress on the vascular endothelium. pGz has been shown to stimulate the release of endothelium derived nitric oxide, prostaglandins and tissue plasminogen activator (tPA) among some of the known products. pGz also supports ventilation, and blood flow during cardiac arrest. The effects of this noninvasive technique on the heart and the vascular endothelium has profound implications in the areas of myocardial preservation, ischemia and reperfusion, and post-ischemic injury. Further, pGz will have important implications for the treatment, and prevention of a host of disease processes. This web page is designed to provide basic visual and text information about pGz and its use in the experimental setting.
|
