Building upon a tradition of over half a century of leadership in cardiovascular disease, the Miami Heart Research Institute has embarked upon an exciting and ambitious research agenda. We recognize the overwhelming need for resources devoted to developing new and promising initiatives, as well as the emerging role of institutional collaboration.
Miami Heart Research Institute is actively pursuing research programs in stem cell research, cardiovascular genetics, innovations in congestive heart failure, cardiac care of the elderly, emerging imaging capabilities, stress reduction, heart disease in the Hispanic population, long-term follow-up after heart surgery, dietary prevention of heart disease and noninvasive cures for coronary heart disease.
In order to pursue such a vigorous program we’ve combined the efforts of our outstanding staff of skilled researchers with experts from the Mayo Clinic, Columbia University, Mount Sinai and the University of Miami. By combining these sophisticated efforts with our active programs of outreach, education and prevention, we are able to rapidly transmit scientific advancement into community service. The future of cardiac research is very bright and exciting, and at Miami Heart Research Institute, it is now!
THE 2016 RESEARCH RECIPIENTS/PROJECTS ARE:
- Dr. Nanette Bishopric will investigate molecular changes seen in cardiac hypertrophy (enlargement/thickening of the heart), looking into the signal that leads to this abnormal thickening and ways to inhibit that kind of heart condition.
- Dr. Chunming Dong will study the molecular mechanisms by which cocaine effects the cardiovascular system, thereby laying the groundwork for targeting interventions. Cocaine use increases both heart rate and blood pressure, while it constricts the arteries supplying blood to the heart, decreasing oxygen supply. This often causes a heart attack even in healthy people. Cocaine accounts for almost one-third of emergency room visits for drug abuse.
- Dr. Robert Myerburg plans to study family members of patients who have Long-QT syndrome to identify the genetic mutation that underlies this condition. The Long-QT syndrome is a defect of the heart's electrical activity that may cause dangerous, fast and chaotic heartbeats (arrhythmias) that can result in sudden death.
- Dr. Lina Shehadeh will look into the cellular mechanisms underlying fibrosis of the heart which is a pathologic thickening of the heart which leads to abnormal relaxation of the muscle, a process that contributes to the development of heart failure.
2013-2014 RESEARCH PROJECTS FUNDED:
- Bilateral Internal Mammary Artery (BIMA) Grafting in Elderly Patients - Malcolm J. Dorman, MD; Paul A. Kurlansky, MD; Ernest A. Traad, MD; David L. Galbut, MD; Melinda Zucker, BSN; George Ebra, EdD
- Cell Model - Jose Adams, MD, Mount Sinai Medical Center, Miami Beach
- Combined Gene and Engineered Stem Cell Therapy Treatment of Acute Myocardial Infarction – Keith Webster, PhD, University of Miami
- Decoding Repair Signatures in Cardiopoitic Stem Cell Treated Heart Failure Patients (Stem Cell Based Heart Repair) – Andre Terzik, MD, PhD, Mayo Clinic, Rochester, Minnesota
- Periodic (pGz) Acceleration and Cardiac Enzymes - Jose Adams, MD, Mount Sinai Medical Center, Miami Beach
- Smooth Muscle Cell Transdifferentiation: A New Paradigm for Cardiac Regeneration – Lina Shehadeh, PhD, University of Miami
- The Contrast Nephropathy and Nitrates Trial – Gervasio A Lamas, MD, Mount Sinai Medical Center, Miami Beach
- The Role of C-Myc in Pulmonary Hypertension – Claudia Rodrigues, PhD, University of Miami